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KMID : 0369319920120030314
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Allergy
1992 Volume.12 No. 3 p.314 ~ p.319
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Inhibitory Effects of Ethanol Feeding on Active Systemic Anaphylaxis in Mice
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Abstract
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There has been a numbers of reports that demonstrates that the administration of ethanol results in a number of immunological abnormalities, including an impaired humoral and cellular immune responses, an increased suceptivility in infection and
a
decreased NK cell activity. Recently, Gonzales et al showed that ethanol inhibited Con A- and somatostatin-stimulated histamin release from rat mast cells. This study was attempted to investigate whether ethanol feeding to mice may inhibit the
active
systemic anaphylaxis(ASA) induced by chicken-gamma globulin (CGG) or egg albumin(OVA). Mice were fed ad libitum both pellet and 10% ethanol solution in their drinking water for 44, 72 or 80 days before sensitization. Mice were sensitized by i.p.
injection of 500ug CGG or OVA, 1.0mg alumn and 2×10E9 Bordertella pertussis in 0.5ml PBS and were challenged by i.v. injection of 0.25ml PBS containing 500ug CGG or OVA 18 days after sensitization. Shock was scored 30 min after challenge as
descrebed
previously. Ethanol feeding for 44 80 days inhibited ASA induced by OVA and ethanol feeding for 72 days also inhibited CGG-induced ASA. Taken together, it can be concluded that ethanol feeding may inhibit the induction of ASA induced by CGG or
OVA
and
that further studies are necessary to clarify the underlying mechanisms to accounting for this inhibition.
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KEYWORD
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